But the rest of the letter is vague on what Facebook will specifically do to push its 1.8 billion users, and the world, toward globalization.
Zuckerberg's statement is a political one, given nationalist movements that have sprung up in several countries, including the USA with the election of President Donald Trump.
"Our greatest opportunities are now global - like spreading prosperity and freedom, promoting peace and understanding, lifting people out of poverty, and accelerating science", he wrote.
Facebook has detailed its next focus, one building upon the foundation of the company's original focus: 'bringing us all together as a global community.' This isn't a one-company job, Facebook acknowledges, saying the task is bigger than any single organization.
-How do we help people build a safe community that prevents harm, helps during crises and rebuilds afterwards in a world where anyone across the world can affect us?
Regal Real Fight Back to Beat Napoli 3-1
Karim Benzema struck back for Real Madrid though, heading home after a ideal cross from Dani Carvajal to make it 1-1 in the 18th. James Rodriguez has committed his future to Real Madrid after stating he wanted to stay at the Bernabeu "for many years".
The post - which makes no mention of Facebook as a business - is likely to fuel speculation about Zuckerberg's interests beyond steering the social media giant to greater profitability.
He also addressed critics who believe that Facebook has not done enough to combat fake news, including posts that some people said influenced the presidential election - an idea which Zuckerberg previously called "pretty insane".
How do we help people build a civically-engaged community in a world where participation in voting sometimes includes less than half our population? "Yet now, across the world, there are people left behind by globalisation, and movements for withdrawing from global connection".
The company released a reference design for a camera shaped like a U.F.O. that can capture 360-degree video.
He also responded to critics who say Facebook enabled the spread of misinformation and sensationalist news stories by promising to better inform its users about the nature of content being shared.
Man found dead with zip-ties around neck inside jewelry store
Customers said Gholian's store is not one that anyone could walk into, with visitors having to be buzzed in by someone inside. The victim's family asked for privacy at their home in Brooklyn. "I saw him twice this week I was shocked when I heard".
It's not the first time that Zuckerberg, Facebook's co-founder and CEO, has ventured into talking politics, nor will it likely be the last.
Zuckerberg kicked off the conference by making a veiled jab at Donald Trump.
"Instead of building walls, we can help build bridges", he said, as he explained that connecting the world is key to Facebook's future.
"I hear fearful voices calling for building walls and distancing people they label as others", he said on that stage a year ago.
GOP bill would allow states to defund Planned Parenthood
Louise Slaughter (N.Y.) said, adding, "It's high time we recognize that women can make decisions for themselves". Congress has investigated Planned Parenthood's involvement in harvesting and selling fetal tissue.