FC Barcelona's Lionel Messi, second right, kicks the ball to score during the Spanish La Liga soccer match between FC Barcelona and Osasuna at the Camp Nou stadium in Barcelona, Spain, Wednesday, April 26, 2017.
Osasuna are now bottom of the table with just 18 points, a defeat away against the league leaders coupled with a win for Leganes at home versus Las Palmas, would mean they would not be able to catch the side who are now fourth from bottom.
Barca took 11 minutes to break the deadlock, as the visiting defence allowed Lionel Messi to break clear and he went on to lift the ball past the advancing Sirigu for the 501st goal of his Camp Nou career.
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Andre Gomes and Paco Alcacer also scored twice for Barcelona, and Javier Mascherano netted his first goal with the Catalan club to complete the rout.
Regular substitute Alvaro Morata again proved he has more ability than that of an understudy by opening the scoring inside a minute and Rodriguez made it 2-0 before 15 minutes were up. "But, with the way we played, we deserved to win by a wide margin". "From the month of May we will have time to recover and there are lots of positives today". "We've lacked both points and luck, and when that's the case it's hard to turn things around".
Andre Gomez, Arda Turan, Denis Suarez and Lucas Digne all started for Barca, but the league leaders quickly took control of the game and Leo Messi opened the scoring in the 12th minute when he intercepted a loose ball from Fausto Tienza before advancing an clipping the ball over Salvatore Sirigu in the visitors' goal.
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Luis Enrique has admitted he wishes Barcelona had Real Madrid's fixture run-in.
Roberto Torres' lovely free-kick shortly after half-time made it 2-1 but in the end it was mere consolation for bottom-of-the-table Osasuna, who hours after the defeat had their relegation confirmed by Leganes' 3-0 home win against Las Palmas.
But ex-Reds chief executive Ayre, now managing director of 1860 Munich, told Liverpool John Moores University students: "I remember the sporting director of Barcelona calling me during that game, immediately as Suarez bit the player, and he said to me 'My friend, he's bitten somebody, how can this be the price?'" After [Osasuna] got back to 2-1 we were able to put the foot on the accelerator and close the game out.
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"The way we played, we deserved to win by a large margin".