Leroy Sane grabbed a second moments before Aguero chipped in with his 29th goal of the season to seal victory.
Guardiola is convinced that the top two spots are already accounted for by Chelsea and Tottenham Hotspur and that Arsenal, Liverpool, City and United are battling for the other two Champions League places.
"I don't like it really, as I have played all of my career in attack and I am happy to play there", he said.
"Vincent is a central defender who doesn't only win all the duels, but reads the game and passes well", Guardiola told BT Sport.
"This season and last we missed him a lot", the manager said. I know how important he is to the fans, what he has done here and he has huge, huge quality.
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A Security Council press statement has no binding power, but to issue them approval from all 15 members is required in principle. The language on North Korea's nuclear program was more straightforward.
With 20 minutes to go Yoshida had the golden chance to make up for allowing Kompany to rise above him and score when he found space at the far post, only to head straight down into the hands of under-fire City stopper, Bravo.
Pep Guardiola's side are third, seven points clear of fifth-placed Everton.
Despite spending heavily in recent seasons, City's title aspirations have been hampered by an inability to build a consistent, reliable central defensive partnership in Kompany's absence.
They could register three Premier League wins in a row for the first time under Claude Puel.
Guardiola won the Champions League with Barcelona on two occasions but failed to do so with Bayern Munich and faces a challenging task in attempting to get City to the summit of European football.
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The party's gold era, he said, will coincide with India's golden era and it will emerge as a great nation in the world. The Prime Minister stressed that "there should be no conflict within the Muslim community over the issue".
Guardiola's men also have the FA Cup to look forward to, with a game against Arsenal scheduled in the semi-finals next weekend. Southampton, meanwhile, sit safely in mid-table with 40 points from 31 games.
Southampton had barely got out of their own half for the first 15 minutes, but out of nothing they created the best opportunity of the opening period only for Dusan Tadic to blaze over from 15 yards out.
"In Spain, especially in Germany, the pressure is higher to the players, to the manager, to everybody - here it is calm", said the two-time Champions League victor.
Manchester City have only lost one of their last 10 league matches, winning five and drawing four.
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The Raptors aren't listing anyone as out right now, but DeMar DeRozan is battling an illness and listed as questionable. Robin Lopez scored 18 points and Jimmy Butler and Jerian Grant had 17 apiece to pace the Bulls.