Fourth-seed Nadal is on a semi-final collision course with defending champion Novak Djokovic, and the Serbian takes on Joao Sousa of Portugal.
Djokovic turned to the retired eight-time grand slam victor on the eve of the year's second major after admitting he had been in "crisis" for much of the last 10 months.
Djokovic, 30, found little resistance from Granollers, grabbing two breaks early on in the first set and powering to a 6-3 6-4 6-2 victory.
Paire, described prior to their encounter on Court Suzanne Lenglen as a unsafe opponent by Nadal, played with more freedom in a closer second set as the Spaniard lost his edge.
The 12-time grand slam champion parted company with his entire coaching team earlier this month, admitting he needed to rediscover his spark after some disappointing results this year including a second-round exit at the Australian Open.
"Last year, I started to feel I had to change something", Djokovic told French sports daily L'Equipe.
MSM's right-wing bias costs Corbyn 'fair' coverage, says BBC veteran Dimbleby
According to Labour, only 40% of two-year-olds now qualify for free childcare, while some families of three and four-year-olds also miss out.
"I'm very happy to be back here after what happened past year". I'm going to try to use the time spent with him as best as we can.
"That definitely came from the people around me".
Wozniacki, who appeared to be carrying the after-effects of a lower back injury that forced her to retire during last week's Strasbourg tournament, pulled away towards the end of a testy encounter, winning 6-4, 3-6, 6-2 in just over two hours.
Germany's Zverev lost the first set but battled back to win the second before play was called off for the day with the score at 4-6 6-3.
Ryan addresses budget office score of GOP health care bill
Lately, he says , he's seen more people coming to the ER with substance abuse and mental health problems. But, he says, no matter how efficient a state can be, with less funding they can only do so much.
Nadal remains the bookmakers' choice to win his 10th title here, something no one on the men's or women's tours has done at any major in the open era, which began in 1968.
Nadal was largely happy, saying: "I'm always at the start, happy for the victory".
Stan Wawrinka is safely through to the second round of the French Open after a 6-2, 7-6 (6), 6-3 win over Jozef Kovalik of Slovakia.
The Spaniard won nine of the last 10 games to close out the match in just under two hours.
Other seeded men advancing included No. 7 Marin Cilic and No. 10 David Goffin, while No. 14 Jack Sock, the top-ranked United States of America man, and No. 31 Gilles Simon - both in Nadal's section of the draw - plus No. 32 Mischa Zverev all lost.
Croatian Marin Cilic, the seventh-seed, beat Latvia's Ernests Gulbis 6-3 6-3 6-3.
Trump Is Worried About The Trade Deficit With Germany. He Shouldn't Be
On her part, Merkel said India has proved to be a reliable partner and the two sides have been able to deepen cooperation. Modi said Germany has prime place in skilling India's youth, adding that the two countries are "made for each other".