US-led coalition aircraft bombed pro-Syrian regime forces Thursday that "were advancing well inside an established de-confliction zone", according to a statement issued by Operation Inherent Resolve, the official name for the coalition fighting ISIS.
A US defence official said the convoy had not responded to numerous warnings that it was "getting too close to coalition forces".
A member of the US -backed Syrian rebel forces told Reuters the convoy comprised Syrian and Iranian-backed militias and was headed toward the Tanf base when they clashed with some rebel forces.
Each time USA forces attack the Syrian government and their allies, it becomes more likely that someone on their side will retaliate against USA forces in Syria or Iraq, and before we know it we could be mired in fighting against several new enemies that we didn't have before.
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Russian Deputy Foreign Minister Gennady Gatilov also said the strikes had targeted "the Syrian armed forces".
The US-led global coalition struck on Thursday in Southern Syria forces of a militia supporting the regime of President Assad, announced the command of Operation Inherent Resolve, the official name for the coalition fighting ISIS ("Islamic State in Iraq and Syria").
President Donald Trump ordered a missile strike against the Syrian government in April in response to a chemical attack by the Assad regime on its own people.
In this case, an official told The Associated Press, Russia tried multiple times to contact the Syrian forces.
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Two months of USA -backed rebel advances against Islamic State militants have allowed them to secure swaths of territory in the Badia, alarming the Syrian government and its allies. "It (Thursday's strike) is utterly unacceptable and a violation of Syria's sovereignty".
The US launched a direct airstrike against pro-Syrian forces who advanced inside a "de-conflicted zone" even though Russian Federation urged them not to, the Washington-led coalition said. According to reports, the strikes were originally intended as a show of force to deter a 20-vehicle pro-regime convoy from heading toward the base.
The convoy was hit on Thursday as it neared a group of US-backed rebels and a Western special forces unit in Tanf.
The Syrian Observatory for Human Rights said the strike killed eight militiamen, and a Syrian opposition media group, the Palmyra News Network, also said there were casualties from the attack. When they did not, the US fighter jets targeted some of the Syrian vehicles and opened fire.
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U.S. Defense Secretary Jim Mattis said America's role in Syria's conflict was unchanged.