"Six inning and two runs and we won the game".
Arenado hit the first pitch he saw from All-Star closer Mark Melancon (1-2) into the left-field seats to cap a four-game sweep.
The Rockies third baseman was mobbed at home plate by teammates as the crowd chanted "MVP!"
The Rockies now have the best record in the National League with a record of 46-26.
Arendo's heady play at third base short-circuited San Francisco in the fourth. He has 15 home runs and 55 RBIs in 2017.
Carlos Estevez (4-0), called up from the minors before the game, struck out one batter in the ninth for the win.
Cleveland came into the series trailing the Twins by two games in the AL Central. Eduardo Escobar and Eddie Rosario followed with RBI hits to put Minnesota on the board.
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Andrew Miller worked a hitless ninth for his first save of the season.
Cincinnati almost rallied all the way back from an 8-1 deficit in the sixth inning. Nice rebound outing for Blach, who was rocked for seven earned runs by the Royals in his last outing. Heading into Sunday, two of the three cycles to be completed this season have been at Coors, but to a pair of road teams. Carl Edwards Jr., Hector Rondon and Brian Duensing finished up for the Cubs. Taillon gave up eight hits in five innings while striking out four. He hit a 91 miles per hour fastball for his 15th homer and first career cycle.
NY dropped its sixth consecutive game and completed a disappointing 1-6 West Coast trip.
Luis Cessa (0-1) allowed four runs and five hits in four innings for NY.
PHILADELPHIA - Rey Fuentes belted a tiebreaking homer to center in the top of the 10th inning to help lift Arizona to a win over Philadelphia.
The right-hander's lack of command caught up with him in the fifth inning.
The Rockies had a chance to take command in the fourth, opening the frame with back-to-back singles by Arenado and Mark Reynolds.
The closer got his first save opportunity since June 8, and like that day in Milwaukee, Melancon couldn't hold on. He will try to shake off those critical dingers when he brings a 4.23 ERA and 1.23 WHIP into a home start against the Mets next time out.
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They have also made the right choices on which foils to use on the ends of their daggerboards. Out team's really hungry to keep learning, keep moving forward, keep improving.
DETROIT - Steven Souza Jr.'s first career grand slam highlighted a parade of five home runs to lead Tampa Bay to victory over Detroit.
Hitting a walk-off home run is impressive on its own, and hitting the cycle is one of baseball's most rare feats for a game. But on Father's Day it was perfectly fitting.
A career.199 hitter in 176 at-bats coming in, deGrom also provided the biggest jolt.
TORONTO - Russell Martin and Kendrys Morales hit two-run homers, J.A. Happ pitched into the seventh inning and Toronto defeated Chicago.
Logan Morrison had two of the Rays' home runs to reach 21 for the season, a two-run blast to right in the first and a solo shot in the seventh. Ryan Goins tripled home Steve Pearce against Anthony Swarzak (3-2) for the tiebreaking run two batters later.
It was his second game-ending homer in the majors and the eighth cycle in club history.
Camargo hit a one-out infield single off Drew Steckenrider (0-1) and moved to third on Ender Inciarte's line-drive single up the middle.
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Griner remained hospitalized at MedStar Hospital after getting shot in the ankle and Sava described her in good condition. Hodgkinson was injured in a shootout with police and later died of his injuries, according to officials.