Kerber made no effort to hide her frustration during the 1 hour, 22 minute match - her body language coupled with the pained look on her face said it all.
The German will be happy to leave Roland Garros behind, and hope to rediscover a game in which several cylinders are misfiring in time for Wimbledon, where she finished runner-up a year ago.
"Well", Makarova said when informed of the history made by her victory, "that's unbelievable".
"Wimbledon should be much more relaxed afterwards", she said.
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Although maybe not, considering how Kerber has fared lately. Kerber's loss places her game in question. Normally I can move well, but on clay, it's always different and hard for me.
American Bethanie Mattek-Sands belts a backhand during her win. "My father did not like it that I throw my racket, I think". I'm happy with the game, of course, but it wasn't really about the game today.
Kerber's best showing during the clay court season was reaching the Madrid third round where she retired to Genie Bouchard with a left thigh injury. Makarova then raced to a 3-0 lead in the second set.
Olympic champion Monica Puig sent veteran Italian Roberta Vinci to her 10th first round loss in 13 visits to Paris, winning 6-3, 3-6, 6-2. But that was about it. In the last game, Kerber had seven break points but Makarova fought off each one before holding to win.
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I think it doesnt really matter how I played, but I won, Kvitova said.
In January, Kvitova started doing exercises with the injured hand and in April, the left-handed Czech reported "good progress" in her recovery. "Gave her a big hug".
Elsewhere, men's seeded players Dominic Thiem and Grigor Dimitrov swept their opponents, while local favorite Lucas Pouille had to come back from 2-1 down to edge compatriot Julien Benneteau in full sets.
Sunday's matches delivered a major shock when world No. 1 Angelique Kerber was knocked out by Russia's Ekaterina Makarova 6-2, 6-2.
Elsewhere on day one, Great Britain's Dan Evans, making his main draw debut at the French Open, claimed the first set against Tommy Robredo before struggling with the heat and losing in four. Kerber lost convincingly to Ekaterina Makarova, 6-2, 6-2 and is now out of the French Open.
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