Nadal, seeking a record 10th championship at the clay-court major, overwhelmed Roberto Bautista Agut 6-1, 6-2, 6-2 and has dropped only 20 games so far.
"He's a friend whom I appreciate very much", Nadal said of Carreno Busta.
Second seed Karolina Pliskova advanced to round four with a 7-5, 6-1 victory over Germany's Carina Witthoeft.
"And yet I fully respect each opponent and I respect the tournament itself, and each situation, as well".
In the quarterfinals, Nadal will face Pablo Carreno Busta, while Djokovic meets Dominic Thiem.
Wonder Woman breaks records, lassoing in over $200 million internationally
Warner Bros. revised revised the film's weekend estimate up to $103.1 million U.S. from its earlier figure of $100.5 million US. They're about women as well.' - Jeff Goldstein, Warner Bros.
Raonic had caught a break en route to the fourth round when he needed less than a half hour to complete a third-round victory.
The Scot was stretched to his limits in the first two sets against Juan Martin del Potro, but romped through the third 6-0 where he now awaits the victor of the suspended tie between John Isner and Karen Khachanov. World number one Novak Djokovic has never triumphed in Paris.
Two weeks past his 21st birthday, unseeded Karen Khachanov of Russian Federation became the youngest man to reach the French Open's fourth round since 2009, beating 21st-seeded American John Isner 7-6 (1), 6-3, 6-7 (5), 7-6 (3).
The rain delay from Saturday helped Japan's Kei Nishikori as he recovered from a wrist injury and back treatment to beat Hyeon Chung 7-5, 6-4, 6-7 (4), 0-6, 6-4 of South Korea when their third-round match resumed Sunday.
Kristina Mladenovic ensured the host nation will have two women in the quarter-finals for the first time since 1994 after dumping out fourth seed Muguruza 6-1, 3-6, 6-3. I'm very happy to be in the quarters of the French once again.
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Former No. 1 Caroline Wozniacki returned to the French Open quarterfinals for the first time since 2010, eliminating 2009 champion Svetlana Kuznetsova 6-1, 4-6, 6-2. I'm not satisfied with this, of course, ' he said after the match. That was only the second time that Djokovic lost a final set by the score of 6-0 in his 937 career tour-level matches.
Pliskova, who had won just twice in five previous French Open appearances before this year, will face Paraguay's Veronica Cepede Royg for a quarter-final spot.
Croatian qualifier Petra Martic upset 17th-seeded Anastasija Sevastova 6-1 6-1 to reach the fourth round of the French Open.
In a match dubbed "the final before the final", Romanian Simona Halep plays Ukraine's Elina Svitolina.
NY students can apply for free college tuition beginning Wednesday
The application is available through the Higher Education Services Corp., or HESC, the state agency that coordinates student aid. As a resident assistant, he gets free room and board - something that the Excelsior Scholarship does not cover.
This was the second year in a row that Bacsinszky beat seven-time major champion Venus Williams in the fourth round in Paris. His best result came in 2014 when he reached the quarter-finals.