"Ajax are deeply saddened by the news that Appie Nouri has been diagnosed with serious and permanent brain damage", Ajax tweeted on Thursday.
The club statement said the chances of recovery from the damage is nil.
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Nouri has been cleared to leave hospital in Innsbruck and will be transferred to Amsterdam in the coming days, Ajax said.
The Netherlands underage global was airlifted to hospital in Innsbruck, Austria after suffering a cardiac arrhythmia during Ajax's game against Werder Bremen.
Ajax had said Tuesday a preliminary scan and other neurological tests had not detected any anomalies, and that 20-year-old Nouri would be gradually awoken from an induced coma for more detailed examinations.
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The incident occurred after the 70th minute of the game, when he collapsed suffering from cardiac arrhythmia, which is an irregular heartbeat.
Nouri made his debut for Ajax in September 2016 and played 15 games.
Nouri made his debut for Ajax in September a year ago in a Dutch Cup match against Willem II, scoring a goal.
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"This the worst possible message". It is awful. We feel enormously for his parents, siblings and other relatives. This also hit Ajax hard, even though we knew we had to keep this scenario in mind. They were uncertain days, lots of people in different ways have sympathised with his situation and is greatly appreciated. "Unfortunately we'll never know how far his star would have risen". Last season he was chosen as best player in the Jupiler League, where he played with Jong Ajax.