Several vehicles were involved, including a lorry.
"There were many people with blood on their bodies and then the vehicle that had been forced down into the ditch with the lorry was surrounded by many men who were trying their hardest to get out the people inside... the emergency services were incredible but honestly it was the worst crash I've ever seen".
Huge queues built up behind the crash scene after the motorway was closed in both directions.
The force said the collision happened between junction 16 near Almondsbury and junction 14 near Falfield.
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That score, with 8:52 remaining, was the first against the Blackshirts since the first half last week at OR , a span of 18 drives. Junior running back Mikale Wilbon has been sound in his first career start, posting career highs in both carries in yards.
Police are asking people to avoid the area.
He was one of the first at the scene alongside a passing GP and different doctors to help a harmed lady who was in one of the autos.
South Western Ambulance Service Trust said a dozen ambulances and a critical care team were working at the scene.
The lorry that has crashed has hit what M5 commuters will know as a familiar landmark, a windsock next to the road. The southbound carriageway is also closed but has been cleared of traffic and diversions are in place.
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Traffic tailed back for up to six miles as emergency services came to the aid of the injured.
A statement read: "Road users further afield intending to travel through this area should consider alternative routes and allow plenty of extra time for their journey".
Interstates England said the "early desire" is that the M5 "will stay shut in the two bearings late into tonight".
Analyst's Viewpoint About United Natural Foods, Inc. (UNFI), Steel Dynamics, Inc. (STLD)
The FY18 guidance should better reflect organic revenue trends following the heavy wave of acquisition activity in FY16. Peregrine Capital Management LLC grew its position in United Natural Foods by 2.0% during the 2nd quarter.