After guiding the team to survival last season, the former Tottenham manager brought 14 players into the club in the Transfer Window, but has not seen results improve.
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Brown has joined Harry Redknapp (Birmingham) and Gary Caldwell (Chesterfield) on the scrap heap following a night of carnage in the managerial arena.
Blues confirmed his exit online, and also announced that Lee Carsley will take caretaker charge of the club following Redknapp's exit.
The one time candidate for the England manager's job leaves the former Premier League club second bottom of the Championship with only Bolton Wanderers below them.
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"I am disappointed. It's been hard, I have had one week with a new team and new players, one week".
"I made the players aware at half-time that I expected more from them in the second half", Preston boss Alex Neil said.
But this season they have picked up only four points in their opening eight matches and sit 23rd in the Championship table.
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The minister also said that those who can afford vehicle shouldn't be complaining about this price hike and must bear it for the sake of the country.
Carsley has a growing reputation in the game and is believed to be high on the list of candidates for the job, with former Middlesbrough boss Aitor Karanka believed to be keen on the role, as is Redknapp's former assistant Steve Cotterill.