The 31-year-old star, who is now showing off his dancing skills on the latest season of ABC's Dancing With The Stars, said that a number of health issues including nine concussions and many "mini-strokes"- known as TIA's (Transient Ischemic Attack) means he draws a blank when trying to recall some of his fondest memories.
"I'm not saying those things correlate exactly to why my memory's not great, but I guess if you think about it, it could be", he said. "Things pop back into my mind I should have remembered", he said of his severe memory loss in his rehearsal video. "I will tell him, 'Remember this, remember that on 'Malcolm?' What a life!" "Remember that from 'Malcolm"?"
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Cranston starred with Muniz in 151 episodes of Malcolm.
"It's something I never really talked about... I hope we have a lot more memories [together]".
Detailing what happens to his body during one of his episodes, he said: "First, I lose my peripheral vision and I can see people but I can't recognise them".
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Muniz, who suffered a serious auto crash in 2009 while competing as a professional race-car driver, has also endured several concussions - but he says his health battle doesn't affect his desire to work in Hollywood "at all". To stay with the Most Memorable Year theme, Muniz said he chose to focus on the present.
He doesn't know what the cause of his memory loss is but it could be related to injuries sustained during his career racing cars. It's not something I've looked into. "There's no negative feelings, I just don't necessarily remember". "I didn't really take them in".
Christopher Kennedy Masterson, Jane Kaczmarek, Bryan Cranston, Justin Berfield, Frankie Muniz and Erik Per Sullivan on "Malcolm in the Middle". "Every time I go to the doctors, they tell me I'm just insane", he laughed.
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Earlier on the episode, she suffered a tearful meltdown over whether the vacation home they were in was safe. "I get it. The episode showed Kim's horror on full display as she found out how different her body looked in the pictures shot.