San Francisco 49ers at Indianapolis Colts - 10/8/17 NFL Pick, Odds, and Prediction

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The 49ers will try to end their four-game losing streak when they face the Indianapolis Colts on Sunday (10 a.m. PT/1p.m. ET, FOX, DirecTV). San Francisco has lost last three in points of difference of three or less telling us that the team has the fire to win but only lacks in execution.

The 49ers defense has weak points.

Today, the 49ers are 1.5-point underdogs, with many football experts across the nation expecting a low scoring affair. He led the team in rushing as a rookie with 608 yards and then quickly developed into a star in his second season. The Colts improved to 2-1 at home, also defeating Cleveland in Lucas Oil.

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He also had 50 pounds of explosives and 1,600 rounds of ammunition in his vehicle in the hotel parking lot according to police. Marilou Danley , girlfriend of Las Vegas mass murderer Stephen Paddock , is seen in a Facebook photo .

Rookie defensive lineman Solomon Thomas played his best game as a professional last week against Arizona. To Gore's credit, he was the more effective back in the passing attack with three catches for 38 yards on four targets compared to Mack's one catch for two yards. Thomas needs to continue to build this week and find ways to beat Colts' left tackle Anthony Castonzo. This is an offensive line with leakiness in the run game and continued issues in pass protection. We've had a few times where we've needed a big play, and it's been there and we've come up just short. Their quarterback, Brian Hoyer, completed 7-of-8 passes for 73 yards on the opening drive, finding former Colts receiver Pierre Garcon five times alone for 51 yards, but the Indy defense stiffens at its own 10-yard line.

More high-quality play from special teams. On a day when the team honored Manning by retiring his number 18 jersey, Vinatieri came through in the clutch once again with a game-winning field goal in overtime.

Mostert's strong preseason earned him a spot on the 49ers' regular season roster. This is probably the "easiest" game on the rest of the Colts schedule. All three weeks that he has started, he has been great to start the game all the way through the first half. Hyde has a team-high 321 yards rushing this season and has a pair of touchdowns on the ground. The 49ers have played better in recent weeks, but are still looking for that first victory of the season. I still think Taylor is due to break a long run, possibly returning a punt for a touchdown today.

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The extent to which Paddock may have profited from his casino gambling was not clear. Paddock booked one room for August 1, 2017 - two days before the festival started.

The following week though, facing division rival Arizona, Hoyer and the 49ers offense reverted back to the form we've become accustomed to seeing this season.

And in that game, Hoyer looked competent. Brissett does bring some value with his legs and should be able to to extend plays and drives as a result, but against a solid Niners front seven I don't see him having a ton of success in this one.

Gore asked media members how the Niners were doing, praised the direction the team was headed in under the new regime led by coach Kyle Shanahan and general manager John Lynch and had good things to say about numerous players, including the defensive line, safeties Jaquiski Tartt and Eric Reid and Hyde.

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Danley, who was in the Philippines when the shooting occurred, flew back to the United States and is cooperating with authorities. Authorities have been trying to reconstruct Paddock's movements leading up to the deadliest mass shooting in modern USA history.

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