The attack took place near the provincial capital of El-Arish during Friday prayers, police officials said.
Witnesses said the explosive device was detonated next to the Al-Rawdah mosque in the center of the town of Bir al-Abd, according to Egyptian newspaper Al-Masry Al-Youm.
Dozens of people are thought to have been killed or injured after a massive suspected suicide attack on a Mosque in the Egyptian province of Sinai.
Egyptian defense officials said the attack began with explosions and then assailants began firing with machine guns into the mosque.
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Militants in the area have declared allegiance to Islamic State (ISIS) and carried out a number of attacks in recent years.
Ministry of Health spokesperson Khaled Mujahid said the militants set off a bomb during the attack, and that 75 casualties had been transferred to hospital.
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Egypt has been battling a jihadi insurgency in region since the Arab Spring and overthrow of President Mohamed Morsi in 2013.
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A boat carrying eight North Korean men has washed ashore in the northeastern Japan prefecture of Akita, police said Friday. Japanese police have said they are investigating men discovered on Japan's northern coast who claim they are North Korean.