With Philippe Coutinho to come into this side, there are no signs of this remarkable campaign losing momentum for Barca.
Denis Suárez, Arda Turan, Rafinha Alcantara, Gerard Deulofeu and Aleix Vidal have also been left out amid suggestions that the last four could be shown the exit door during the current January transfer window after having deemed surplus requirements by Valverde.
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Barca boss Ernesto Valverde rested some of his best players for the first leg, including Luis Suarez and Lionel Messi, both of whom could return for the second leg. Messi will, as always, be the best player on the pitch should he feature, but Valverde could choose to give another chance to Jose Arnaiz, 22, who scored in the first leg and is the latest B-team player looking to break into the first team.
"Samuel Umtiti, Paco Alcácer and new signing Philippe Coutinho are all forced absentees, while the FCB coach has also made a decision to leave out Denis Suárez, Arda Turan, Rafinha, Deulofeu and Aleix Vidal".
Despite losing 2-1 at Villarreal, who are now sixth in La Liga, Leganes progressed on away goals having won the first leg 1-0.
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"We just weren't capable of defending the Messi-Alba binomial, a link up which we have seen many times and in the La Liga game here last month we were able to stop it", Unzue said in his postgame news conference. It's true that Celta have to score and they have done that in all their games away from home.
"They are a team who try to dominate the game and they don't want you to have the ball, they put pressure on you high up the field".
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Lionel Messi and Luis Suarez were both given the night off in the first leg, but expect both to feature at some stage on Thursday, and Ousmane Dembele could be set for a start after playing for an hour on the weekend.