While the Panthers didn't make an official announcement, the team posted a picture of Davis on its Twitter page with the word "Respect".
Davis, 34, was Carolina's first-round draft pick in 2005 and has spent his entire career with the Panthers.
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Davis cited the desire to spend more time with his kids after fulfilling his contract with the Panthers, which runs through 2018 after an extra year was tacked on to the deal in August. I signed on for a one-year extension, and I want to complete that.
He tore his ACL three different times, and he became the first professional athlete to return and play after three ACL tears.
Davis was the 2014 Walter Payton Man of the Year for his work with the Thomas Davis Defending Dreams Foundation.
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The mercurial Egyptian is facing a race for fitness ahead of this contest, and his presence for the Reds can not be understated. City come into the game still unbeaten in the league this season, and heavily linked with a move for Arsenal's Alexis Sanchez .
Davis played in and started 15 games this season, only missing Carolina's December 24 game against Tampa Bay while serving a suspension for an illegal hit in the previous week's game.
"I'm pretty sure coming back next year it'll be in a reduced role", Davis told Cersosimo.
Davis was suspended for one game late in the season for a helmet-to-helmet hit on Green Bay Packers receiver Davante Adams.
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The company says that they have spoken to Lee directly, but they discontinued their work with him 2016. Lee is the co-creator of Spider-Man, X-Men, The Hulk and numerous other comic books.