The incident took place on Tuesday after which at least 106 people died.
More than 100 were killed and another 1,200 people were wounded by the Syrian regime shelling and air strikes on Monday on the besieged Damascus suburb, the rebel-held town of Hamouria, the CNN said. "Today, now we are in the midday, we have more than 80 martyrs", a doctor at one of the hospitals told ITV News.
More than 340,000 people have been killed since the civil war erupted in 2011 when protests against Assad's government were brutally crushed. Since the 2013 alleged chemical attack on Eastern Ghouta, the observing committee said the death toll is highest after the 2013 chemical attack.
Ahmad al-Dbis, an official at the Union of Medical Care and Relief Organizations, which runs hospitals and clinics in Syrian opposition areas, says ten hospitals have been damaged by airstrikes or shelling in the last 48 hours.
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But on Tuesday, the Syrian Observatory for Human Rights war monitor said at least 50 civilians, including 13 children, were killed in the second day of air strikes on Eastern Ghouta.
Fighting has raged on in eastern Ghouta even though it falls under the ceasefire plans that Moscow brokered with the help of Turkey and Iran.
Medical supplies were already in short after years-long siege of the area that began in 2012.
The joint bombardment targeted rebel tactical positions, gatherings, equipment and movements across the militant-controlled districts of Douma, Hamourya, Saqba, Zamalka, Ayrn Tarma and Uataya.
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The United Nations (UN) children's fund on Tuesday expressed "outrage" over the killings of children in Syria by issuing a blank statement, adding in a footnote that "no words will do (them) justice". The news agency added that Syrian army has fiercely responded to the attacks by rebel forces by destroying rocket launchers.
The Observatory said the "crazy shelling" appears to be paving the way for a wide ground offensive on eastern Ghouta.
The two main rebel factions in eastern Ghouta, which signed the deals with Russian Federation last summer, accuse Damascus and Moscow of using the jihadist presence as a pretext for attacks.
Rebels retaliated by hitting some Damascus neighbourhoods with mortar shells, killing eight, including three children, and wounding 15 people, according to the state news agency SANA.
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"The Secretary-General reminds all parties, particularly the guarantors of the Astana agreements, of their commitments in this regard", Dujarric said in a statement.