In 2008, a speeding bus careered out of control at a Sai Kung roundabout, leaving 18 people dead and 44 injured.
The police told Xinhua that 17 men and two women were confirmed dead at the scene.
The Hospital Authority said 19 people were in a serious condition.
Firefighters are still at the spot to rescue passengers trapped inside.
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Photos and videos published by local media or posted by users on social media showed the gold-colored bus lying on its side while emergency workers rushed to treat injured passengers nearby. "And then it was like the tyre slipped, and the bus turned".
Photographs of the incident showed the bus on its side with the roof torn off. The police said that they will need to expand the road blog and send more personnel to the scene for the investigation.
A spokesman from the bus company, The Kowloon Motor Bus company, said HK$80,000 (£7,300) would be paid to each victim's family.
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Representatives from the bus operator said on Saturday evening that the driver had a good track record and knew the route, which only runs on race days.
The fire brigade responded at 6:15pm.
In 2003, 21 died and 20 were injured in the worst road traffic accident in Hong Kong history when a KMB double decker bus crashed through a guardrail and down a hill off Tuen Man Road after colliding with a truck.
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