The shooting happened near the military installation's gate off of Route 32 at Canine Road around 7:15 a.m. Wednesday.
The local ABC affiliate reported that three persons were injured and a suspect was arrested.
Larry Whitley, a spokesman for Fort Meade police, said one person was injured in the incident and taken to a hospital.
The Federal Bureau of Investigation confirmed on Twitter that its Baltimore office had sent agents to investigate the incident, its Baltimore office said on Twitter. Shots were fired, according to local media and there are bullet holes in the vehicle, including in the front window.
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US Intelligence chiefs said Tuesday that North Korea will be one of the most confrontational threats to the US this year.
It appeared to have crashed into the NSA-stamped concrete barricade blocks outside the base.
But in early 2015, two people were shot at by NSA police when they disobeyed orders outside the heavily secured campus. "More information will be released as it becomes available".
MD 32 is now closed in both directions at Canine Rd., according to Maryland State Highway Administration.
An external view of the National Security Agency building in the Washington suburb of Fort Meade, Md., is captured on January 25, 2006.
US Reaper drone destroys Russian-made tank in Syria
The attack, according to Reuters , marks the "second defensive strike against pro-government forces in less than a week". Kremlin spokesman Dmitry Peskov refrained from comment, saying on Tuesday that the reports needed to be verified.
Authorities said the situation is under control and there is no ongoing security or safety threat, CBS News correspondent Jeff Pegues reported.
White House deputy press secretary Lindsay Walters said in a statement that President Trump had been briefed on the shooting.
Stay with FOX 5 for the latest on this developing story.
OnePlus teams up with Qualcomm to launch 5G device in 2019
It supports Full Dimension Multi-Input Multi-Output (FD-MIMO), a Massive MIMO technology that is foundational to 5G NR networks. OnePlus has partnered with Qualcomm to launch a 5G device in 2019 by making use of their Snapdragon X50 5G NR modem family.