A Western intelligence agency revealed the accusations to the BBC past year, and claim it is in violation of an agreement by President Bashar al-Assad to destroy the nation's chemical munitions following a 2013 Sarin attack on Damascus.
Observatory chief Rami Abdel Rahman said few rebels were among the dead because they rarely left their tunnels and had better protection from air strikes than civilians, estimated to number around 4,00,000 in Ghouta.
The Observatory said 211 people have been killed in eastern Ghouta since Monday.
"We seek peace but are prepared for any scenario and I wouldn't suggest to anyone that they test us", Netanyahu said during the visit.
"A humanitarian ceasefire would enable the delivery of life-saving assistance and the evacuation of hundreds of critically ill patients urgently needing medical treatment" in Eastern Ghouta, he said.
The operation is being carried out under the framework of Turkey's rights within worldwide law, U.N. Security Council resolutions, its right to self-defense under the U.N. charter and respect for Syria's territorial integrity, it said.
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- Double-tap strike - Jisreen was also hit heavily, with 17 civilians killed on Thursday.
A man holds a child after an airstrike in the besieged town of Douma in eastern Ghouta in Damascus, Syria, February 7, 2018.
Ankara's operation followed USA calls to establish a Kurdish-led "border security force (BSF)" in the future in Syria along the 900-km border with Turkey, a move that has angered Turkey. In the Idlib province that is now held by rebels, six others were killed by air strikes. The Syrian American Medical Society said its hospitals in Idlib treated 11 patients for suspected chlorine gas poisoning.
In 2013, the USA and Russia, Assad's strongest ally, struck an agreement that sought to disarm Syria's arsenal of chemical weapons, which eventually led to the disposal of around 1,200 tons of chemical stockpile.
Escalated attacks have compounded the dire humanitarian situation for the 400,000 people trapped in the opposition enclave with limited access to food and medicine.
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The official says about 100 of the attackers were killed.
Nineteen children and 20 women were among the dead, and around 200 were wounded, said the Britain-based war monitor.
He neither confirmed nor denied Wednesday's raid but said: "The force behind everything is Iran and we must pinpoint the laser on it".
The campaign by the Syrian government and its ally, Russia, has also battered the northwestern province of Idlib, the largest area under opposition control in Syria.
"This morning, Israeli warplanes fired several missiles from Lebanese airspace on one of our military positions in the Damascus countryside", said a Syrian military statement carried by state media.
According to United Nations estimates, 13.1 million people require humanitarian assistance in Syria, including almost 3 million people in hard-to-reach areas.
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