Bush, now age 92, has decided not to seek additional medical treatment and will instead focus on comfort care.
The office of her husband, former president George H.W. Bush, said Sunday the 92-year-old former first lady made the decision following a recent series of hospitalizations and after consulting with her family and doctors.
Barbara has also been a fierce protector and advocate for her family, most recently, helping her son, former Florida governor Jeb Bush, with his presidential campaign in 2016. The other was Abigail Adams, wife of John Adams and mother of John Quincy Adams.
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Both husband and wife have dealt with deteriorating health in recent years.
The statement continued that she appreciated the well wishes she had received and that her family is close to her. She was being treated by bronchitis and the nation's 41st president was being treated for pneumonia.
Bush also revealed her secret for a long life: medical attention. Her husband was president from 1989 to 1993. Bush would travel the world representing the US before turning their sights to The White House, first as the Vice President and Second Lady during the Ronald Reagan administration, then the 1988 Presidential election.
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"I have had great medical care and more operations than you would believe", she told the magazine. She was the first First Lady to throw out a pitch to open the baseball season when she threw out the first pitch at a Texas Rangers game when they were partially owned by her son, George.
The couple met at a Christmas dance in 1941, when Barbara Pierce was 16 and George Bush was 17. After World War II, the Bushes moved to Texas where he went into the oil business.
Extra glass of wine, beer takes 30 minutes off your life
The study is big news for drinkers across the world since countries have different recommendations for alcohol consumption. A 40-year-old who drank up to twice that amount (100 to 200g) cut their life expectancy by six months.