However, Guardiola's side are seeking to recover from a dispiriting run of results, having gone out of the Champions League after losing home and away against Liverpool in the quarter-finals, as well as missing the opportunity to clinch the title against United last weekend.
"It can happen", Guardiola said. As soon as we win the first one, the second one will be easier.
"Since November and December we have already been champions, when I saw pundits and people say: 'Impossible for City to drop points'".
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The City boss said: "Ageruo was injured before the (Liverpool) game but made a huge effort to help us for 10-15 minutes. We are sad we went out of the Champions League, but it's hard to take the way it happened". We have to handle that.
Guardiola cited two examples of high-profile sporting collapses when examining his own team's prospects -â Real Madrid's miserable finish to the 2003-04 La Liga season, and Golden State Warriors' failure to win basketball's NBA finals in 2016.
'It would be better but I am who I am, ' said Guardiola.
The Argentine was on target in City's last win away to Spurs at White Hart Lane in May 2015, but since then City have lost their last two visits away to Spurs, conceding six goals. So of course it can happen, no doubts about that.
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Then came Saturday's suspected chemical attack in Douma, followed by worldwide condemnation and threats of military action. Foreign Minister Sergei Lavrov warned Western intervention in Syria would "lead to new waves of migrants to Europe".
"What I say to the players - and what they show every game - is that it is not done". [In 2016], never before, in the National Basketball Association finals, one team recovered from 3-1 down. We won last five in a row before United. "We don't depend on anyone else, and that's a good advantage", said Guardiola. "We have 14 players plus the kids. Congratulations to the opponents if they beat us".
Nonetheless, Guardiola hopes City will handle the pressure.
He added: "No, I don't think so".
Spurs are undoubtedly a club on the rise, but in order to be classed as a truly top team, they will need to win a trophy sooner rather than later.
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Even if the placed on November's ballot, splitting California into three states would require congressional approval. There's also water rights, state pensions, prisons and education funding. "California dreams big", he said.