Immunotherapy Drug Keytruda Halts 'Untreatable' Prostate Cancer In Some Men


De Bono said that while patients with DNA fix mutations responded to treatment, further investigation is still needed to confirm this.

"Our study has found that immunotherapy can benefit a subset of men with advanced, otherwise untreatable prostate cancer, and these are most likely to include patients who have specific DNA fix mutations within their tumours".

With regard to patients' definitive prostate cancer treatment, 186 (94%) patients had undergone radical prostatectomy (RP) and the remaining 11 (6%) received external beam radiation therapy (EBRT).

The new trial relates to immunotherapy drugs.

Nell Barrie from Cancer research United Kingdom states that the next course of action is to "find out how to tell which men will benefit from taking the drug".

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Your immune system is trained to fight infection, but it also attacks parts of the body if they malfunction - such as in cancers.

Thanks to a new immunotherapy treatment, the men who just had a few weeks or months to live after getting diagnosed with prostate cancer could now survive for longer, a latest trail results showed.

A new study conducted by the Institute of cancer research and the Royal Marsden hospital in London has shown wonderful results in patients with prostate cancer.

The researchers suggest these mutating cancer cells may be easy for the immune system to recognise and attack because they look different from healthy cells.

Professor de Bono said: "We are planning a new clinical trial, specifically in men with prostate cancer whose tumours have mutations in DNA fix genes, to see if immunotherapy can become a standard part of their treatment". Importantly, the medications only work for some patients. However, the researchers were expecting it, since immunotherapy only works for some patients.

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"This is important as although immunotherapy is exciting, it can have severe side effects".

"This new trial has found that testing for mutations in DNA fix genes could be a valuable marker of who will respond".

New prostate cancer drug Keytruda showed promising results in the first major clinical trial to test immunotherapy in some men with advanced prostate cancer.

Eight months of treatment with abiraterone (AA) plus leuprolide for biochemically recurrent non-metastatic hormone-naive prostate cancer (M0HNPC) improves PSA-free survival compared with the use of leuprolide alone, with no delay in testosterone recovery or significant safety concerns, according to data presented at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Illinois, on Monday, June 4.

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