The green, military-style jacket is from the clothing seller Zara.
"It's a jacket. There was no hidden message", Melania's spokeswoman Stephanie Grisham said in a statement to the press.
In a few minutes, people started spoofing the jacket and adding their own messages. Meanwhile, Grisham tweeted annoyance at the media for even asking about the jacket.
Brooks Koepka repeats as US Open champion
He nailed putts as long as 57 feet on No. 2 - a great way to get started - and almost 30 feet on the 15th for his final birdie. And he hung on during a nerve-jangling back nine - he bogeyed the last for some late drama - as long-time leader Johnson faded.
Media personality Toure wondered in a Tweet whether Melania Trump or those around her gave much thought to the message on the jacket.
Update, 5:20 PM: Trump continued to wear the jacket on her flight back to DC on Thursday afternoon. And the color doesn't matter - it's what's written on the back in big white graffiti lettering: "I REALLY DON'T CARE, DO U?". She visited the Upbring New Hope Children's Center there.
Moments after her tour began, photos started circulating online of the first lady boarding the plane for takeoff at Andrews Air Force Base in Maryland. Given the backlash, her team has already responded, denying that the jacket had any significant meaning.
Like it or not, Mrs. Trump's jacket, which reportedly retailed at $39, had her trending on Twitter.
OPEC Works Toward Deal as Saudis Propose Plan for Higher Output
Brent oil prices were up 1.9 per cent on Friday as the output boost had been largely priced in and was seen as modest. Zangeneh also said on Friday OPEC would change the structure of the current deal, but did not elaborate.
Trump blamed media for criticising Melania's clothes of choice for the visit.
The first lady said she wanted to lend her support to the children, and asked staff to reunite them with their families as quickly as possible.
The First Lady had initiated the trip and it was planned before president Trump signed his Executive Order appearing to reverse his family separation policy. This Melania jacket thing can not be real.
"Remember when Michelle Obama showed her bare arms and went to an oil spill, and Fox News went nuts?"
The first lady, a former fashion model, sometimes gets input on wardrobe decisions from her fashion adviser, Herve Pierre. She changed into sneakers before landing, but the heels captured a disproportionate amount of media attention.
Chinese media says United States has 'delusions', urges focus on domestic development
Trump has brushed aside concerns over a trade war, saying the US can't lose because it already has such a significant deficit. Trump claimed America had been obliged to levy the metals tariffs as it has been exploited as the world's "piggy bank".
Her husband, Donald has been criticised around the world for isolating thousands of children from their families in detention centres.